Pulse: Intravenous Immunoglobulin, IgA, and Adverse Events

December 18, 2025

IVIG is indicated in patients with low IG, however sometimes these patients have low-IgA which may be caused by the presence of anti-IgA antibodies. This, in theory, leads to increased risk of hypersensitivity reactions and anaphylaxis. This presentation will increase pharmacist competency in weighing risks versus benefits of using IVIG in patients with low IgA and allow them to make evidence-based recommendations on the use of this medication (as well as lab requests) within that specific population in a way that prioritizes safety.

Target Audience

Pharmacist

Learning Objectives

1. Identify some common indications for chronic and acute IVIG use

2. Explain why there has been controversy surrounding patients with low IgA who need IVIG

3. Describe options in IG therapy for patients where risks are a major concern, but IG therapy is still indicated

Additional Information

Course summary
Available credit: 
  • 1.00 ACPE Pharmacy
    The UPMC Center for Continuing Education in the Health Sciences is accredited by the Accreditation Council for Pharmacy Education (ACPE) as a Provider of continuing pharmacy education.
Course opens: 
12/18/2025
Course expires: 
01/18/2026
Event starts: 
12/18/2025 - 12:00pm EST
Event ends: 
12/18/2025 - 1:00pm EST

IVIG is indicated in patients with low IG, however sometimes these patients have low-IgA which may be caused by the presence of anti-IgA antibodies. This, in theory, leads to increased risk of hypersensitivity reactions and anaphylaxis. This presentation will increase pharmacist competency in weighing risks versus benefits of using IVIG in patients with low IgA and allow them to make evidence-based recommendations on the use of this medication (as well as lab requests) within that specific population in a way that prioritizes safety.

UPMC Presbyterian/ Mercy
Pittsburgh, PA
United States

Kathryn Mazeski, PharmD

 

In support of improving patient care, the University of Pittsburgh is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

 

Pharmacy (CPE)

This knowledge-based activity provides 1.0 contact hours of continuing pharmacy education credit.

 

Available Credit

  • 1.00 ACPE Pharmacy
    The UPMC Center for Continuing Education in the Health Sciences is accredited by the Accreditation Council for Pharmacy Education (ACPE) as a Provider of continuing pharmacy education.
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