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Forward3/10/2026 - Medical Grand Rounds: Ending the HIV Epidemic: Recent Updates and Challenges in HIV Prevention and Cure Research
This course reviews current advances and ongoing challenges in HIV prevention, including oral, injectable, and long‑acting biomedical strategies, adherence barriers, and emerging prevention tools supported by recent clinical trial data. Learners will also explore progress in HIV cure research, highlighting mechanisms of viral persistence, innovative therapeutic approaches, and future directions toward sustained remission or cure.
Learning Objectives
Upon completion of this activity, participants should be able to:
- Describe the clinical and public health rationale for achieving sustained HIV remission without continuous antiretroviral therapy.
- Explain the biological and virologic mechanisms that enable HIV to persist despite currently available antiretroviral therapies.
- Identify key scientific, clinical, and implementation barriers to achieving sustained HIV remission.
- Evaluate emerging and innovative therapeutic strategies under investigation for achieving HIV remission.
- Estimate the likelihood of achieving sustained HIV remission for most persons living with HIV based on current evidence.
- Apply strategies to increase patient linkage to biomedical HIV prevention options, including pre-exposure prophylaxis (PrEP).
- Select the most appropriate HIV prevention options to improve client success based on individual risk profiles and clinical context.
- Improve patient outcomes by appropriately referring patients for post-exposure prophylaxis for sexually transmitted infections.
Sharon Hillier, PhD — Professor of Obstetrics, Gynecology and Reproductive Sciences and Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine
John Mellors, PhD — Distinguished Professor of Medicine, Division of Infectious Diseases, University of Pittsburgh School of Medicine
Disclosures:
No members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships with any companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.
Disclosures:
No members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships with any companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.
Accreditation Statement
In support of improving patient care, the University of Pittsburgh is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.
The University of Pittsburgh designates enduring material activity for a maximum of 1.0 AMA PRA Category 1 Credit[s]™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Other health care professionals will receive a certificate of attendance confirming the number of contact hours commensurate with the extent of participation in this activity.
Available Credit
- 1.00 AMA PRA Category 1 Credit™The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
- 1.00 Attendance