Pharmacogenomics in Practice: Oncology
Pharmacogenomic (PGx) implementation is increasing in the US, especially in the treatment of cancer where there is wide variability in medication response and strong evidence of the impact of germline genetic variation on medication outcomes. Commonly prescribed chemotherapy medications like thiopurines, fluoropyrimidines, and tamoxifen have Clinical Pharmacogenetics Implementation Consortium (CPIC) and/or FDA have PGx-based prescribing guidance. However, clinicians report low knowledge and confidence in using PGx information for adjusting dose or drug selection. This barrier must be overcome by clinicians who are responsible for integrating PGx into their practice to achieve positive outcomes. Learning objectives were carefully developed to achieve the NHGRI's Genome Education genomic education competency standards for all healthcare professionals. Primary care practitioners will achieve these competencies through this enduring training and learn to make clinical decisions that impact medication prescribing in their practice area. A portion of the training focuses on interprofessional care.
Pharmacogenomics in Practice: Oncology
A 5-hour, self-paced, online training for clinicians seeking to integration pharmacogenomics (PGx) in their mental health practice.
Welcome
- Advances in precision medicine and PGx – Philip Empey, PharmD, PhD
- Multidisciplinary roles in PGx – Lucas Berenbrok, PharmD, MS
Foundations of PGx
- Genomics 101 – Philip Empey, PharmD, PhD
- Individualizing care: a review of pharmacology – Todd Skaar, PhD
- Inheritance and medical genetics – Mylynda Massart, MD, PhD
- ELSI & PGx – Lisa Parker, PhD
All about testing - Philip Empey, PharmD, PhD
- Testing technologies
- Landscape of PGx testing
- Interpreting a PGx report
Principles of PGx decision making
- The PGx decision-making process - Philip Empey, PharmD, PhD
- PGx patient care plans – Lucas Berenbrok, PharmD, MS
- Trustworthy online resources:
- CPIC – Kelly Caudle, PharmD, PhD
- PharmGKB – Michelle Whirl-Carillo, PhD
- FDA Resources – Robert Schuck, PharmD, PhD
Integrating PGx into your oncology practice: - Katherine Robinson, PharmD, BCPS
- Germline PGx in oncology
- TMPT-NUDT15 and thipurines
- DPYD and fluoropyridines
- CYP2D6 and tamoxifen
Target Audience
All healthcare professionals, including: Nurses, Nurse Practitioners, Pharmacists, Physicians and Physician Assistants.
Learning Objectives
Upon completion of this activity, participants should be able to:
- Review foundational genomic concepts and nomenclature.
- Describe how PGx variation affects the pharmacokinetics and pharmacodynamics of chemotherapy medications.
- Order quality PGx testing when appropriate for patients across their patient care journey.
- Explain the individual and societal risks and benefits of genetic testing in the healthcare setting.
- Identify gene-drug pairs and seminal clinical trial data with a high level of evidence in oncology.
- Develop a stepwise decision-making process for the integration of PGx with clinical variables (e.g. phenoconversion) that known to impact PK/PD to make appropriate recommendations for oncology patients and populations.
- Identify one's own role and that of other interprofessional team members to apply PGx into practice.
Disclaimer Statement:
The information presented at this activity represents the views and opinions of the individual presenters, and does not constitute the opinion or endorsement of, or promotion by, the UPMC Center for Continuing Education in the Health Sciences, UPMC / University of Pittsburgh Medical Center or Affiliates and University of Pittsburgh School of Medicine. Reasonable efforts have been taken intending for educational subject matter to be presented in a balanced, unbiased fashion and in compliance with regulatory requirements. However, each program attendee must always use his/her own personal and professional judgment when considering further application of this information, particularly as it may relate to patient diagnostic or treatment decisions including, without limitation, FDA-approved uses and any off-label uses.
Faculty:
Planning Committee:
- James Coons, PharmD (University of Pittsburgh School of Pharmacy, Pittsburgh, PA)
- Jill Bates, PharmD, MS (University of North Carolina Medical Center, UNC Eshelman School of Pharmacy, Chapel Hill, NC)
- Lucas Berenbrok, PharmD, MS (University of Pittsburgh School of Pharmacy, Pittsburgh, PA)
- Deepak Voora, MD (Duke University School of Medicine, Department of Medicine, Durham, NC)
- Trina Walker, DNP, APRN, FNP-C (Creighton University, Ohmaha, NE)
- Nguyen Park, MS, PA-C, DFAAPA, (Wayne State University, Detroit, MI)
Course Director:
Philip Empey, PharmD, PhD, FCCP (University of Pittsburgh School of Pharmacy, Pittsburgh, PA)
Presenters (in alphabetical order):
- Lucas Berenbrok, PharmD, MS (University of Pittsburgh School of Pharmacy, Pittsburgh, PA)
- Kelly Caudle, PharmD, PhD, BCPS, FCCS (St. Jude Children's Research Hospital, Memphis, TN)
- Philip Empey, PharmD, PhD, FCCP (University of Pittsburgh School of Pharmacy, Pittsburgh, PA)
- Mylynda Massert, MD, PhD (University of Pittsburgh Department of Pediatrics, Pittsburgh, PA)
- Lisa Parker, PhD (University of Pittsburgh Center for Bioethics & Health Law, Pittsburgh, PA)
- Robert Schuck, PharmD, PhD (Washington University School of Medicine in St. Louis, Department of Pediatrics, St. Louis, MO)
- Todd Skaar, PhD (Indiana University School of Medicine, Indianapolis, IN)
- Katherine Robinson, PharmD, BCPS (University of Pittsburgh School of Pharmacy, Pittsburgh, PA)
- Michelle Whirl-Carillo, PhD (Stanford University, Department of Biomedical Data Science, Stanford, CA)
Conflict of Interest Disclosure:
Dr. Coons discloses that he receives grant/research support from Heart Rhythm Society, and Pfizer-Bristol Myers Squibb Alliance. He is a consultant for Merck and Pfizer-Bristol Myers Squibb Alliance.
No other planners, members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships to disclose.
In support of improving patient care, the University of Pittsburgh is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME) and the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.
Physician (CME)
The University of Pittsburgh designates this enduring material activity for a maximum of 5.0 AMA PRA Category 1 Credit[s]™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Nursing (CNE)
The maximum number of hours awarded for this Continuing Nursing Education activity is 5.0 contact hours.
Physician Assistant (AAPA)
The University of Pittsburgh has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 5.0 AAPA Category 1 CME credits. PAs should only claim credit commensurate with the extent of their participation.
Pharmacy (CPE)
This knowledge-based activity provides 5.0 contact hours of continuing pharmacy education credit.
Other health care professionals will receive a certificate of attendance confirming the number of contact hours commensurate with the extent of participation in this activity.
Available Credit
- 5.00 AAPA Category I CME
- 5.00 ACPE PharmacyThe UPMC Center for Continuing Education in the Health Sciences is accredited by the Accreditation Council for Pharmacy Education (ACPE) as a Provider of continuing pharmacy education.
- 5.00 AMA PRA Category 1 Credit™The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
- 5.00 ANCCUPMC Provider Unit is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center’s Commission on Accreditation
- 5.00 Attendance
PLEASE NOTE: Your NABP and DOB must be in your profile in order to have credits submitted to the ACPE and pharmacy credits awarded.
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