The 2026 Pittsburgh International Lung Conference (PILC) will have a specific focus on "The Evolving Landscape of COPD: Bridging New Mechanisms and Emerging Therapies".  COPD is a leading cause of death worldwide and overcoming challenges in COPD requires multidisciplinary cooperation across multiple fields, including basic and translational science, epidemiology, genetics, bioengineering, computational biology, and clinical research and implementation. The two-day program will include a keynote, seven main sessions covering topics such as the exposome, gene-to-function studies, regenerative medicine, aging, immunity, diagnostics, comorbidities, and biologics, plus a special session on AI. Interspaced with these sessions will be panel discussions, poster sessions, and an evening reception with a lecture by guest speaker, Steven D. Shapiro, MD.