Anatomic Pathology Case of the Month 1060

The UPMC Department of Pathology offers FREE continuing medical education (CME). Certificates and transcripts can be obtained at no charge through the University of Pittsburgh. The CME modules cover a broad range of topics relevant to pathologists and are presented as case reviews and lectures.  While completing your CME requirements, consider the expertise of our faculty in helping you solve difficult clinical problems. 

Topic for this Session:  Covers a rare lung tumor most pathologists are not familiar with.

Target Audience

Physicians and other health care professionals.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Increase awareness of the pathologic evaluation of pulmonary mucoepidermoid carcinoma.

Suggested Additional Reading:

  • Travis WD, Brambilla E, Nicholson AG, Yatabe Y, Austin JHM, Beasley MB, et al. The 2015 World Health Organization classification of lung tumors. J Thorac Oncol (2015) 10(9):1243-60.
  • Kumar, V. et al. A comparative study of primary adenoid cystic and mucoepidermoid carcinoma of lung. Front. Oncol. 8, (2018).
  • Kalhor, N. & Moran, C. A. Pulmonary mucoepidermoid carcinoma: diagnosis and treatment. Expert Rev. Respir. Med. 12, 249-255 (2018).
  • Yousem, S. A. & Hochholzer, L. Mucoepidermoid tumors of the lung. Cancer 60, 1346-1352 (1987).
  • ElNayal, A. et al. Primary Salivary Gland-Type Lung Cancer: Imaging and Clinical Predictors of Outcome. Am. J. Roentgenol. 201, W57-W63 (2013).
  • Molina, J. R. et al. Primary salivary gland-type lung cancer: Spectrum of clinical presentation, histopathologic and prognostic factors. Cancer 110, 2253-2259 (2007).
  • Hsieh, C. C., Sun, Y. H., Lin, S. W., Yeh, Y. C. & Chan, M. L. Surgical outcomes of pulmonary mucoepidermoid carcinoma: A review of 41 cases. PLoS One 12, 1-12 (2017).
  • Achcar, R. D. O. D., Nikiforova, M. N., Dacic, S., Nicholson, A. G. & Yousem, S. A. Mammalian mastermind like 2 11q21 gene rearrangement in bronchopulmonary mucoepidermoid carcinoma. Hum. Pathol. 40, 854-860 (2009).
  • Roden, A. C. et al. Histopathologic, immunophenotypic and cytogenetic features of pulmonary mucoepidermoid carcinoma. Mod. Pathol. 27, 1479-1488 (2014).
  • Brandwein, M. S. et al. Mucoepidermoid carcinoma: A clinicopathologic study of 80 patients with special reference to histological grading. Am. J. Surg. Pathol. 25, 835-845 (2001).
  • Vadasz P and Egervary M. Mucoepidermoid bronchial tumors: a review of 34 operated cas- es. Eur J Cardiothorac Surg 2000; 17: 566- 569.
  • Chin CH, Huang CC, Lin MC, Chao TY and Liu SF. Prognostic factors of tracheobronchial mucoepidermoid carcinoma-15 years experience. Respirology 2008; 13: 275-280.
  • Minnich, D. J., Bryant, A. S., Dooley, A. & Cerfolio, R. J. Photodynamic Laser Therapy for Lesions in the Airway. Ann. Thorac. Surg. 89, 1744-1749 (2010).
  • Monaco, S. E., Khalbuss, W. E., Ustinova, E., Liang, A. & Cai, G. The cytomorphologic spectrum of salivary gland type tumors in the lung and mediastinum: A report of 16 patients. Diagn. Cytopathol. 40, 1062-1070 (2012).
  • Shahi, M., Dolan, M. & Murugan, P. Hyalinizing Clear Cell Carcinoma of the Bronchus. Head Neck Pathol. 11, 575-579 (2017).
  • Shah, A. A. et al. EWSR1 Genetic Rearrangements in Salivary Gland Tumors. Am. J. Surg. Pathol. 37, 571-578 (2013).
Course summary
Available credit: 
  • 0.50 AMA PRA Category 1 Credit™
    The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
  • 0.50 Attendance
Course opens: 
Course expires: 

Course Director and Planning Committee:

Karen E Schoedel, MD - Professor of Pathology, Member of the Division of Anatomic Pathology, University of Pittsburgh

Course Directors:

Paul Ohori, MD - Professor of Pathology, Medical Director of Cytopathology, University of Pittsburgh

Daniel Martinez Coconubo, MD - PGY4, Department of Pathology, University of Pittsburgh

Conflict of Interest Disclosure:
No planners, members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships to disclose.

In support of improving patient care, the University of Pittsburgh is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physician (CME)

The University of Pittsburgh School designates this live activity for a maximum of 0.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Other Healthcare Professionals

Other health care professionals will receive a certificate of attendance confirming the number of contact hours commensurate with the extent of participation in this activity.

Disclaimer Statement:

The information presented at this activity represents the views and opinions of the individual presenters, and does not constitute the opinion or endorsement of, or promotion by, the UPMC Center for Continuing Education in the Health Sciences, UPMC / University of Pittsburgh Medical Center or Affiliates and University of Pittsburgh School of Medicine.  Reasonable efforts have been taken intending for educational subject matter to be presented in a balanced, unbiased fashion and in compliance with regulatory requirements. However, each program attendee must always use his/her own personal and professional judgment when considering further application of this information, particularly as it may relate to patient diagnostic or treatment decisions including, without limitation, FDA-approved uses and any off-label uses.

Available Credit

  • 0.50 AMA PRA Category 1 Credit™
    The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
  • 0.50 Attendance
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