Anatomic Pathology Case of the Month 1084

The UPMC Department of Pathology offers FREE continuing medical education (CME). Certificates and transcripts can be obtained at no charge through the University of Pittsburgh. The CME modules cover a broad range of topics relevant to pathologists and are presented as case reviews and lectures.  While completing your CME requirements, consider the expertise of our faculty in helping you solve difficult clinical problems. 

Topic for this Session:  Review the pathologic and molecular features of papillary renal cell carcinoma with reverse polarity.

Target Audience

Physicians and other health care professionals.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Describe the pathologic and molecular features of papillary renal cell carcinoma with reverse polarity.

Suggested Additional Reading:

  • Delahunt B, Eble JN, McCredie MR,  et al. Morphologic typing of papillary renal cell carcinoma: comparison of growth kinetics and patient survival in 66 cases. Hum Pathol. 2001;32(6):590-595.
  • Saleeb RM, Plant P, Tawedrous E, et al. Integrated Phenotypic/Genotypic Analysis of Papillary Renal Cell Carcinoma Subtypes: Identification of Prognostic Markers, Cancer-related Pathways, and Implications for Therapy. Eur Urol Focus. 2018;4(5):740-748. 
  • Saleeb RM, Brimo F, Farag M, et al. Toward Biological Subtyping of Papillary Renal Cell Carcinoma With Clinical Implications Through Histologic, Immunohistochemical, and Molecular Analysis. Am J Surg Pathol. 2017;41(12):1618-1629. 
  • Chevarie-Davis M, Riazalhosseini Y, Arseneault M, et al. The morphologic and immunohistochemical spectrum of papillary renal cell carcinoma: study including 132 cases with pure type 1 and type 2 morphology as well as tumors with overlapping features. Am J Surg Pathol. 2014;38(7):887-894. 
  • Trpkov K, Hes O, Williamson SR, et al. New developments in existing WHO entities and evolving molecular concepts: The Genitourinary Pathology Society (GUPS) update on renal neoplasia. Mod Pathol Off J U S Can Acad Pathol Inc. 2021;34(7):1392-1424.
  • Kunju LP, Wojno K, Wolf JS, Cheng L, Shah RB. Papillary renal cell carcinoma with oncocytic cells and nonoverlapping low grade nuclei: expanding the morphologic spectrum with emphasis on clinicopathologic, immunohistochemical and molecular features. Hum Pathol. 2008;39(1):96-101.
  • Al-Obaidy KI, Eble JN, Cheng L, et al. Papillary Renal Neoplasm With Reverse Polarity: A Morphologic, Immunohistochemical, and Molecular Study. Am J Surg Pathol. 2019;43(8):1099-1111.
  • Wei S, Kutikov A, Patchefsky AS, et al. Papillary Renal Neoplasm With Reverse Polarity Is Often Cystic: Report of 7 Cases and Review of 93 Cases in the Literature. Am J Surg Pathol. Published online August 5, 2021.
  • Kiyozawa D, Kohashi K, Takamatsu D, et al. Morphological, immunohistochemical, and genomic analyses of papillary renal neoplasm with reverse polarity. Hum Pathol. 2021;112:48-58.Zhou L, Xu J, Wang S, et al. Papillary Renal Neoplasm With Reverse Polarity: A Clinicopathologic Study of 7 Cases. Int J Surg Pathol. 2020;28(7):728-734.
  • Kim SS, Cho YM, Kim GH, et al. Recurrent KRAS mutations identified in papillary renal neoplasm with reverse polarity—a comparative study with papillary renal cell carcinoma. Mod Pathol. 2020;33(4):690-699.Chang HY, Hang JF, Wu CY, et al. Clinicopathological and molecular characterization of papillary renal neoplasm with reverse polarity and its renal papillary adenoma analogue. Histopathology. 2021;78(7):1019-1031.
Course summary
Available credit: 
  • 0.50 AMA PRA Category 1 Credit™
    The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
  • 0.50 Attendance
Course opens: 
04/16/2022
Course expires: 
04/16/2025

Course Director and Planning Committee:

Karen E Schoedel, MD - Professor of Pathology, Member of the Division of Anatomic Pathology, University of Pittsburgh

Course Directors:
Gabriela M. Quiroga-Garza, MD - Assistant Professor of Pathology, Department of Pathology, University of Pittsburgh
Daniel Geisler, MD - Department of Pathology, University of Pittsburgh

Conflict of Interest Disclosure:
No planners, members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships to disclose.

 

In support of improving patient care, the University of Pittsburgh is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physician (CME)

The University of Pittsburgh School designates this live activity for a maximum of 0.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Other Healthcare Professionals

Other health care professionals will receive a certificate of attendance confirming the number of contact hours commensurate with the extent of participation in this activity.

Disclaimer Statement:

The information presented at this activity represents the views and opinions of the individual presenters, and does not constitute the opinion or endorsement of, or promotion by, the UPMC Center for Continuing Education in the Health Sciences, UPMC / University of Pittsburgh Medical Center or Affiliates and University of Pittsburgh School of Medicine.  Reasonable efforts have been taken intending for educational subject matter to be presented in a balanced, unbiased fashion and in compliance with regulatory requirements. However, each program attendee must always use his/her own personal and professional judgment when considering further application of this information, particularly as it may relate to patient diagnostic or treatment decisions including, without limitation, FDA-approved uses and any off-label uses.

Available Credit

  • 0.50 AMA PRA Category 1 Credit™
    The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
  • 0.50 Attendance
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