Case 1059 A Young Male with Abdominal Pain and a Para-spinal Mass
The UPMC Department of Pathology offers FREE continuing medical education (CME). Certificates and transcripts can be obtained at no charge through the University of Pittsburgh. The CME modules cover a broad range of topics relevant to pathologists and are presented as case reviews and lectures. While completing your CME requirements, consider the expertise of our faculty in helping you solve difficult clinical problems.
Topic for this Session: Review knowledge gaps with regard to the understanding of anaplastic large cell lymphoma.
Physicians and other health care professionals.
Upon completion of this activity, participants should be able to:
- Apply morphologic, immunohistochemical and molecular features to differentiate ALK+ALCL from other lymphomas.
Suggested Additional Reading:
- Swerdlow S.H.C.E., Harris N.L., Jaffe E.S., Pileri S.A., Stein H., Thiele J., Arber D.A., Hasserjian R.P., Le Beau M.M., Orazi A., et al. WHO Classification of Tumours of Hematopoietic and Lymphoid Tissues. 4th ed. International Agency for Research on Cancer (IARC); Lyon, France: 2017.
- Foss HD, Anagnostopoulos I, Araujo I, Assaf C, Demel G, Kummer JA, Hummel M, Stein H. Anaplastic large-cell lymphomas of T-cell and null-cell phenotype express cytotoxic molecules.Blood.1996;88:4005-4011.
- Della Corte, C.M., Viscardi, G., Di Liello, R. et al. Role and targeting of anaplastic lymphoma kinase in cancer. Mol Cancer 17, 30 (2018).
Touriol, Christian & Greenland, Catherine & Lamant, Laurence & Pulford, Karen & Bernard, Frederic & Rousset, Thérèse & Mason, David & Delsol, Georges. (2000). Further demonstration of the diversity of chromosomal changes involving 2p23 in ALK-positive lymphoma: 2 cases expressing ALK kinase fused to CLTCL (clathrin chain polypeptide-like). Blood. 95. 3204-7.
- Ruth H. Palmer, Emma Vernersson, Caroline Grabbe, Bengt Hallberg; Anaplastic lymphoma kinase: signaling in development and disease. Biochem J 15 June 2009; 420 (3): 345-361.
- Zhang Q, Ming J, Zhang S, Li B, Han X, Qiu X. Cytokeratin positivity in anaplastic large cell lymphoma: a potential diagnostic pitfall in misdiagnosis of metastatic carcinoma. Int J Clin Exp Pathol. 2013;6(4):798-801.
- Webb TR, Slavish J, George RE, et al. Anaplastic lymphoma kinase: role in cancer pathogenesis and small-molecule inhibitor development for therapy. Expert Rev Anticancer Ther. 2009;9(3):331-356.
- Azarova AM, Gautam G, George RE. Emerging importance of ALK in neuroblastoma. Semin Cancer Biol. 2011;21:267-275.
Qiu Y, Li B, Zhang Y, et al. ALK-rearranged lung adenocarcinoma patient with development of severe sinus bradycardia after treatment with crizotinib: A case report. Medicine (Baltimore).2019;98(11):e14826.
- Lin JJ, Zhu VW, Schoenfeld AJ, et al. Brigatinib in Patients With Alectinib-Refractory ALK-Positive NSCLC. J Thorac Oncol. 2018;13(10):1530-1538.
Course Director and Planning Committee:
Karen E Schoedel, MD - Professor of Pathology, Member of the Division of Anatomic Pathology, University of Pittsburgh
Davsheen Bedi, MBBS, MD - Resident, Department of Pathology, University of Pittsburgh
Nidhi Aggarwal, MD - Assistant Professor of Pathology, Department of Pathology, University of Pittsburgh
Conflict of Interest Disclosure:
No planners, members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships to disclose.
In support of improving patient care, the University of Pittsburgh is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.
The University of Pittsburgh School designates this live activity for a maximum of 0.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Other Healthcare Professionals
Other health care professionals will receive a certificate of attendance confirming the number of contact hours commensurate with the extent of participation in this activity.
The information presented at this activity represents the views and opinions of the individual presenters, and does not constitute the opinion or endorsement of, or promotion by, the UPMC Center for Continuing Education in the Health Sciences, UPMC / University of Pittsburgh Medical Center or Affiliates and University of Pittsburgh School of Medicine. Reasonable efforts have been taken intending for educational subject matter to be presented in a balanced, unbiased fashion and in compliance with regulatory requirements. However, each program attendee must always use his/her own personal and professional judgment when considering further application of this information, particularly as it may relate to patient diagnostic or treatment decisions including, without limitation, FDA-approved uses and any off-label uses.
- 0.50 AMA PRA Category 1 Credit™The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
- 0.50 Attendance
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