3/19/2026 Anesthesiology Grand Rounds -Liposomal Bupivacaine: The Good, The Bad, The Ugly - Steve Orebaugh, MD

This activity reviews the pharmacology and proposed mechanisms of action of liposomal bupivacaine, examining the basic science rationale alongside clinical studies that both support and challenge its effectiveness. Learners will critically evaluate evidence across multiple surgical and regional anesthesia applications, explore factors contributing to inconsistent efficacy, and discuss considerations for appropriate use, safety, and future research.

Target Audience

Anesthesiologists and anesthesiologists-in-training and other anesthesia professionals, nurse anesthetists and anesthesia assistants.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Explain the pharmacologic properties and mechanisms of action of liposomal bupivacaine (LB).
  • Summarize the early basic science evidence supporting the use of liposomal bupivacaine.
  • Critically appraise clinical studies that both support and do not support the use of liposomal bupivacaine.
  • Identify the key requirements necessary to achieve effective neural blockade.
  • Analyze potential factors contributing to failed efficacy of liposomal bupivacaine.
Course summary
Available credit: 
  • 1.00 AMA PRA Category 1 Credit™
    The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
  • 1.00 Attendance
Course opens: 
03/19/2026
Course expires: 
03/19/2029
ISER
United States

Steve Orebaugh, MD — Professor, Anesthesiology and Perioperative Medicine Director, Outpatient Orthopedic Anesthesiology, UPMC Montefiore Co-Chair, Residency Curriculum Committee

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In support of improving patient care, the University of Pittsburgh is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physician (CME)

The University of Pittsburgh designates this enduring material activity for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Other Healthcare Professionals
Other health care professionals will receive a certificate of attendance confirming the number of contact hours commensurate with the extent of participation in this activity.
 

Available Credit

  • 1.00 AMA PRA Category 1 Credit™
    The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
  • 1.00 Attendance
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