With marijuana legalization expanding across the United States, school-aged children and adolescents are increasingly exposed to cannabis products—both intentionally and unintentionally. Misperceptions of safety, potent new formulations (such as Delta-8 THC and cannabis “wax”), and the rise in edible exposures have created new challenges for school health professionals. This presentation provides school nurses with an up-to-date review of the epidemiology, neurobiological effects, and health risks of cannabis use in youth. Participants will learn how marijuana impacts brain development, cognition, learning, and behavior, as well as how it contributes to academic difficulties and psychosocial consequences. Case examples and current research data will be discussed to illustrate real-world presentations of cannabis exposure and use among students. The session emphasizes early identification, student assessment, family communication, and evidence-based prevention and referral strategies. By the end of this course, school nurses will be better prepared to recognize warning signs, provide informed education, and collaborate effectively with families and school personnel to promote student safety and well-being.