Contraindication of Using Nirmatrelvir-Ritonavir (Paxlovid™) With Clozapine

This training is designed to address mental health care professionals who may not realize that medication is under EUA, making it less likely that clinicians and patients and the population at large are aware of life-threatening drug-drug interactions with medications that are highly dependent on CYP3A4 for clearance (e.g., Paxlovid™) which in addition to COVID-19’s impact on the hepatic cytochromes may result in serious medical consequences for individual patients

Target Audience

This course is designed for health care professionals including physicians, other prescribers, pharmacists, nurses, patients and caregivers, among others.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Describe the mechanism of action of Paxlovid™
  • Recognize and recall drug-drug interactions between Paxlovid™ and certain antipsychotics
  • Identify clinical indications and considerations for a patient prescribed clozapine and Paxlovid™.
Course summary
Available credit: 
  • 0.50 ACPE Pharmacy
    The UPMC Center for Continuing Education in the Health Sciences is accredited by the Accreditation Council for Pharmacy Education (ACPE) as a Provider of continuing pharmacy education.
    • 0.50 Patient Safety/Risk Management
  • 0.50 AMA PRA Category 1 Credit™
    The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
    • 0.50 Patient Safety/Risk Management
  • 0.50 ANCC
    UPMC Provider Unit is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center’s Commission on Accreditation
    • 0.50 Patient Safety/Risk Management
  • 0.50 Attendance
    • 0.50 Patient Safety/Risk Management
Course opens: 
12/09/2022
Course expires: 
12/09/2025

Planning Committee:

Joan Spinogatti - Administrative Coordinator, CRS, Office of the Service Line Chief - CRS, UPMC Western Psychiatric Hospital

Course Directors:

  • K.N. Roy Chengappa, MD, MRCPsych - Professor of Psychiatry, Service Line Chief, Comprehensive Recovery Service, UPMC
  • Melanie Yabs, PharmD, MS, BCPP - Clinical Pharmacist, Psychiatry, UPMC Western Psychiatric Hospital
  • Joe Zimmerman, MSN, RN, CNL, CPPS - Director, Quality and Patient Safety UPMC Western Psychiatric Hospital

Conflict of Interest Disclosure:
No planners, members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships to disclose.

In support of improving patient care, the University of Pittsburgh is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME) and the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physician (CME)
The University of Pittsburgh designates this enduring material activity for a maximum of 0.5 AMA PRA Category 1 Credit[s]™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nursing (CNE)
The maximum number of hours awarded for this Continuing Nursing Education activity is 0.5 contact hours.

Pharmacy (CPE)
This knowledge-based activity provides 0.5 contact hours of continuing pharmacy education credit.

Other health care professionals will receive a certificate of attendance confirming the number of contact hours commensurate with the extent of participation in this activity.

Available Credit

  • 0.50 ACPE Pharmacy
    The UPMC Center for Continuing Education in the Health Sciences is accredited by the Accreditation Council for Pharmacy Education (ACPE) as a Provider of continuing pharmacy education.
    • 0.50 Patient Safety/Risk Management
  • 0.50 AMA PRA Category 1 Credit™
    The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
    • 0.50 Patient Safety/Risk Management
  • 0.50 ANCC
    UPMC Provider Unit is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center’s Commission on Accreditation
    • 0.50 Patient Safety/Risk Management
  • 0.50 Attendance
    • 0.50 Patient Safety/Risk Management
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