Pulse - ARB We Choosing the Correct Antihypertensive? The Effect of Angiotensin II on Cognitive Impairment_enduring
New medications and new guidelines are constantly being released. Pharmacists need a mechanism to keep up with these new medications and guidelines.
Hypertension has been studied extensively showing a correlation in the decline of cognitive function and is known to be a modifiable risk factor. However, it is still unknown if the benefit of controlling hypertension in regard to cognitive impairment is due to the reduction of blood pressure or through alternative mechanisms of the renin-angiotensin system, specifically angiotensin II. Antihypertensive medications work on the renin-angiotensin system in various ways, and it is hypothesized that certain medications have more protective properties than others. The clinical significance of the selection between antihypertensive medications and their effect on cognitive impairment and dementia remains in question. This presentation will discuss recent evidence exploring if angiotensin receptor blockers (ARBs) compared to angiotensin-converting inhibitors (ACE-inhibitors) provide a better protection in people who do or not have pre-existing cognitive impairment.
Target Audience
Pharmacist
Learning Objectives
- Describe the relationship between hypertension, the renin-angiotensin system, and cognitive impairment in older adults.
- Discuss evidence comparing angiotensin receptor blockers (ARBs) versus angiotensin-converting inhibitors (ACE inhibitors) effect on cognitive impairment
- Recognize how the evidence comparing the antihypertensives would apply to clinical practice
Additional Information
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New medications and new guidelines are constantly being released. Pharmacists need a mechanism to keep up with these new medications and guidelines.
Hypertension has been studied extensively showing a correlation in the decline of cognitive function and is known to be a modifiable risk factor. However, it is still unknown if the benefit of controlling hypertension in regard to cognitive impairment is due to the reduction of blood pressure or through alternative mechanisms of the renin-angiotensin system, specifically angiotensin II. Antihypertensive medications work on the renin-angiotensin system in various ways, and it is hypothesized that certain medications have more protective properties than others. The clinical significance of the selection between antihypertensive medications and their effect on cognitive impairment and dementia remains in question. This presentation will discuss recent evidence exploring if angiotensin receptor blockers (ARBs) compared to angiotensin-converting inhibitors (ACE-inhibitors) provide a better protection in people who do or not have pre-existing cognitive impairment.
Camryn Vecera, PharmD
In support of improving patient care, the University of Pittsburgh is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.
Pharmacy (CPE)
This knowledge-based activity provides 1.0 contact hours of continuing pharmacy education credit.
Available Credit
- 1.00 ACPE PharmacyThe UPMC Center for Continuing Education in the Health Sciences is accredited by the Accreditation Council for Pharmacy Education (ACPE) as a Provider of continuing pharmacy education.