Treating Insulin Resistance as A Strategy to Improve Outcome in Treatment-Resistant Bipolar Depression: Results From The Trio-BD Study

March 30, 2022

This presentation is dedicated to the memory of Patricia Schlicht. Clinical Research Coordinator of the TRIO-BD Study -Pittsburgh Site

Could restoring insulin sensitivity help reduce symptoms of depression in people with treatment-resistant bipolar disorder?  In this presentation we will review of the results of a small, proof-of-concept clinical trial conducted at the University of Pittsburgh and Dalhousie University in Nova Scotia, Canada.  

Target Audience

MDs, Pharmacists, and other mental health clinicians, nurses, and psychologists.

Learning Objectives

1.To learn how to test patients for insulin resistance.
2.To understand the importance of treating insulin resistance in treatment-resistant bipolar depression.
3.To understand how treating insulin resistance with metformin can improve short- and intermediate-term outcomes.

Additional Information

AttachmentSize
PDF icon Handout Final.pdf139.4 KB
Course summary
Available credit: 
  • 1.00 AMA PRA Category 1 Credit™
    The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
  • 1.00 Attendance
Course opens: 
01/04/2022
Course expires: 
06/30/2022
Event starts: 
03/30/2022 - 12:00pm EDT
Event ends: 
03/30/2022 - 1:00pm EDT

Wednesday, March 30, 2022 (Virtual: Microsoft TEAMS meeting)
12:00 to 1:00 pm

Live Virtual Conference

Microsoft Teams meeting

Faculty listing:
K. N. Roy Chengappa, MD, FRCPC – Professor of Psychiatry, UPMC Western Psychiatric Hospital and the University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania

Cynthia V. Calkin, MD, CCFP, FRCPC - Associate Professor of Psychiatry & Medical Neuroscience
Dalhousie University, Faculty of Medicine
Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia Health

Jessica M. Gannon, MD - Associate Professor of Psychiatry, UPMC Western Psychiatric Hospital and the University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania

Faculty Disclosure:
No members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships with any entity producing, marketing, re-selling, or distributing health care goods or services, used on, or consumed by, patients to disclose.

Disclaimer Statement
The information presented at this CME program represents the views and opinions of the individual presenters, and does not constitute the opinion or endorsement of, or promotion by, the UPMC Center for Continuing Education in the Health Sciences, UPMC / University of Pittsburgh Medical Center or Affiliates and University of Pittsburgh School of Medicine.  Reasonable efforts have been taken intending for educational subject matter to be presented in a balanced, unbiased fashion and in compliance with regulatory requirements. However, each program attendee must always use his/her own personal and professional judgment when considering further application of this information, particularly as it may relate to patient diagnostic or treatment decisions including, without limitation, FDA-approved uses and any off-label uses.

Accreditation and Designation Statement
In support of improving patient care, the University of Pittsburgh is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physician (CME)
The University of Pittsburgh designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Other health care professionals will receive a certificate of attendance confirming the number of contact hours commensurate with the extent of participation in this activity. 

Available Credit

  • 1.00 AMA PRA Category 1 Credit™
    The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
  • 1.00 Attendance
Please login or register to take this course.


For more information, contact Joan Spinogatti at spinogattij@upmc.edu or 412-246-5006