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ForwardPulse: Clozapine After REMS: Rethinking ANC Monitoring in a New Era
Clozapine remains the most effective antipsychotic for treatment-resistant schizophrenia, yet ANC monitoring practices vary widely and are often more conservative than current evidence supports. With the discontinuation of the REMS program, many clinicians are uncertain about appropriate monitoring frequency and safety considerations. This presentation will equip pharmacists to apply evidence-based ANC monitoring strategies and support safe, streamlined clozapine management.
Target Audience
Pharmacist
Learning Objectives
1. Describe the rationale for ANC monitoring in patients on clozapine and review its role in mitigating the risk of agranulocytosis.
2. Discuss the impact of the REMS program discontinuation on ANC monitoring requirements and patient safety considerations.
3. Evaluate the literature on ANC monitoring to guide evidence-based pharmacist recommendations and support clinical decision-making in clozapine management
Additional Information
| Attachment | Size |
|---|---|
 Disclosure + Objective Slides_AZ2025_Angeleki Zecopoulos.pdf | 317.28 KB |
 How to access credits - Code access.doc | 98.5 KB |
Clozapine remains the most effective antipsychotic for treatment-resistant schizophrenia, yet ANC monitoring practices vary widely and are often more conservative than current evidence supports. With the discontinuation of the REMS program, many clinicians are uncertain about appropriate monitoring frequency and safety considerations. This presentation will equip pharmacists to apply evidence-based ANC monitoring strategies and support safe, streamlined clozapine management.
Angeleki Zecopoulos, PharmD
In support of improving patient care, the University of Pittsburgh is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.
Pharmacy (CPE)
This knowledge-based activity provides 1.0 contact hours of continuing pharmacy education credit.
Available Credit
- 1.00 ACPE PharmacyThe UPMC Center for Continuing Education in the Health Sciences is accredited by the Accreditation Council for Pharmacy Education (ACPE) as a Provider of continuing pharmacy education.