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ForwardPulse: Shaking Things Up: Examining the Role of Novel Anti-Seizure Medications in Refractory Status Epilepticus
The initial management strategies for status epilepticus are well defined in the guidelines, but limited evidence exists for recommendations to treat refractory status epilepticus or partial response to initial therapies. Novel anti-seizure medications such as brivaracetam, perampanel, cenobamate, and cannabidiol have shown some promise as adjunctive treatments for refractory status epilepticus, but their specific place in therapy has not been firmly established.
Target Audience
Pharmacist
Learning Objectives
1. Define the pathophysiology of refractory status epilepticus and the current guideline recommendations for management
2. Discuss the mechanisms of action of the novel anti-seizure medications brivaracetam, perampanel, cenobamate, and cannabidiol and the evidence for the use of these medications in refractory status epilepticus
3. Identify the circumstances favoring the use of novel anti-seizure medications and make recommendations for their place in our treatment of refractory status epilepticus
Additional Information
| Attachment | Size |
|---|---|
 Audience Disclosure slide_35.pptx | 461.67 KB |
 Hausberger Handout.pdf | 168.03 KB |
The initial management strategies for status epilepticus are well defined in the guidelines, but limited evidence exists for recommendations to treat refractory status epilepticus or partial response to initial therapies. Novel anti-seizure medications such as brivaracetam, perampanel, cenobamate, and cannabidiol have shown some promise as adjunctive treatments for refractory status epilepticus, but their specific place in therapy has not been firmly established.
Clayton Hausberger, PharmD
In support of improving patient care, the University of Pittsburgh is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.
Pharmacy (CPE)
This knowledge-based activity provides 1.0 contact hours of continuing pharmacy education credit.
Available Credit
- 1.00 ACPE PharmacyThe UPMC Center for Continuing Education in the Health Sciences is accredited by the Accreditation Council for Pharmacy Education (ACPE) as a Provider of continuing pharmacy education.