Tumor Lysis Syndrome
This online training module, part of the Emergency Medicine – Oncology Nursing Training series, focuses on Tumor Lysis Syndrome (TLS), a rare but life-threatening oncology emergency that demands rapid recognition and intervention. Designed for both new and experienced RNs with limited oncology exposure, the activity covers TLS risk factors, signs and symptoms, prevention strategies, and management protocols—empowering nurses to respond confidently and effectively to oncology emergencies and improve patient outcomes.
Target Audience
Learning Objectives
- Identify clinical signs and symptoms indicative of Tumor Lysis Syndrome.
- Compare and evaluate prophylactic strategies used to prevent Tumor Lysis Syndrome.
- Select and interpret appropriate diagnostic tests for confirming Tumor Lysis Syndrome.
- Formulate and implement evidence-based treatment plans for patients diagnosed with Tumor Lysis Syndrome.
COURSE DIRECTORS:
- Danielle Brightshue, BSN, RN, CEN -Professional Staff Nurse Expert, UPMC Shadyside Emergency Department
- Jaylan Lunsford, BSN, RN, CEN - Professional Staff Nurse Expert, UPMC Shadyside Emergency Department
PLANNING COMMITTEE:
- Ruth Fisher, MSN, RN, CEN, EMT-P - Unit Director, UPMC Shadyside Emergency Department
- Breanna Unger, BSN, BS, RN, CEN, EMT-P - Senior Clinican, UPMC Shadyside Emergency Department
CONFLICT OF INTEREST DISCLOSURE:
No planners, members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships to disclose.
DISCLAIMER STATEMENT
The information presented at this CME program represents the views and opinions of the individual presenters, and does not constitute the opinion or endorsement of, or promotion by, the UPMC Center for Continuing Education in the Health Sciences, UPMC / University of Pittsburgh Medical Center or Affiliates and University of Pittsburgh School of Medicine. Reasonable efforts have been taken intending for educational subject matter to be presented in a balanced, unbiased fashion and in compliance with regulatory requirements. However, each program attendee must always use his/her own personal and professional judgment when considering further application of this information, particularly as it may relate to patient diagnostic or treatment decisions including, without limitation, FDA-approved uses and any off-label uses.

In support of improving patient care, the University of Pittsburgh is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.
Nursing (ANCC)
The maximum number of hours awarded for this Continuing Nursing Education activity is 0.5 contact hours.
Other health care professionals will receive a certificate of attendance confirming the number of contact hours commensurate with the extent of participation in this activity.
Available Credit
- 0.50 ANCCUPMC Provider Unit is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center’s Commission on Accreditation
- 0.50 Attendance

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