Pulse: Assessing the need for GI prophylaxis with DAPT and triple therapy

May 22, 2024

New medications and new guidelines are constantly being released. Pharmacists need a mechanism to keep up with these new medications and guidelines.

The goal of this presentation is to provide rationale based on literature findings to support the use or to recommend against the use of GI prophylaxis when DAPT, triple therapy, or various combinations of antiplatelets and anticoagulants are used. This is a relevant topic seen often in the acute care setting, where GI prophylaxis is added in almost every case. Looking further into the literature and actual incidence of adverse effects will be useful when deciding if GI prophylaxis is warranted.

Target Audience

Pharmacist

Learning Objectives

1. Describe the mechanism of action of aspirin, P2Y12 inhibitors, and DOACs and how these may increase the need for PPIs and H2RAs.

2. Identify the risk of GI bleeding with various combinations of P2Y12 inhibitors, antiplatelets, and/or anticoagulants along with assessing the risks and benefits of GI prophylaxis.

3. Discuss the findings from literature evaluating GI prophylaxis with the combination therapies.

Additional Information

AttachmentSize
File Audience Disclosure slide_26.pptx460.29 KB
Course summary
Available credit: 
  • 1.00 ACPE Pharmacy
    The UPMC Center for Continuing Education in the Health Sciences is accredited by the Accreditation Council for Pharmacy Education (ACPE) as a Provider of continuing pharmacy education.
Course opens: 
05/22/2024
Course expires: 
06/22/2024
Event starts: 
05/22/2024 - 12:30pm EDT
Event ends: 
05/22/2024 - 1:30pm EDT

New medications and new guidelines are constantly being released. Pharmacists need a mechanism to keep up with these new medications and guidelines.

The goal of this presentation is to provide rationale based on literature findings to support the use or to recommend against the use of GI prophylaxis when DAPT, triple therapy, or various combinations of antiplatelets and anticoagulants are used. This is a relevant topic seen often in the acute care setting, where GI prophylaxis is added in almost every case. Looking further into the literature and actual incidence of adverse effects will be useful when deciding if GI prophylaxis is warranted.

UPMC Presbyterian
Pittsburgh, PA
United States

Kenzie Zamberlan, PharmD

 

In support of improving patient care, the University of Pittsburgh is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

 

Pharmacy (CPE)

This knowledge-based activity provides 1.0 contact hours of continuing pharmacy education credit.

 

Available Credit

  • 1.00 ACPE Pharmacy
    The UPMC Center for Continuing Education in the Health Sciences is accredited by the Accreditation Council for Pharmacy Education (ACPE) as a Provider of continuing pharmacy education.
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