Pulse: Into the Blue: Methylene Blue's Role in Septic Shock
Patients who develop sepsis and septic shock face a high mortality risk. The mainstay of therapy to combat the vasodilatory effects of septic shock are volume resuscitation and vasopressors such as catecholamines and vasopressin. Some studies show that the addition of methylene blue can help decrease catecholamine doses and decrease ICU and hospital length of stay. This presentation will focus on the role of methylene blue in septic shock and determining effective dosing strategies and implementation of therapy.
Target Audience
Pharmacist
Learning Objectives
a. Describe standard resuscitation care for patients with septic shock
b. Discuss proposed use of methylene blue in patients with septic shock
c. Identify the most effective dosing strategy for methylene blue in septic shock patients
Additional Information
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Patients who develop sepsis and septic shock face a high mortality risk. The mainstay of therapy to combat the vasodilatory effects of septic shock are volume resuscitation and vasopressors such as catecholamines and vasopressin. Some studies show that the addition of methylene blue can help decrease catecholamine doses and decrease ICU and hospital length of stay. This presentation will focus on the role of methylene blue in septic shock and determining effective dosing strategies and implementation of therapy.
Frances Callahan, PharmD
In support of improving patient care, the University of Pittsburgh is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.
Pharmacy (CPE)
This knowledge-based activity provides 1.0 contact hours of continuing pharmacy education credit.
Available Credit
- 1.00 ACPE PharmacyThe UPMC Center for Continuing Education in the Health Sciences is accredited by the Accreditation Council for Pharmacy Education (ACPE) as a Provider of continuing pharmacy education.

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