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ForwardPulse: Insulin Infusion: A Therapeutic Approach to Managing Severe Hypertriglyceridemia
New medications and new guidelines are constantly being released. Pharmacists need a mechanism to keep up with these new medications and guidelines.
Insulin is considered for severe hypertriglyceridemia due to its ability to rapidly lower triglyceride levels through mechanisms such as enhancing lipoprotein lipase activity and reducing hepatic gluconeogenesis. However, the practice lacks standardized guidelines and poses risks like hypoglycemia, necessitating further research to establish optimal dosing, protocols, and long-term outcomes. More randomized controlled trials and mechanistic studies are needed to refine treatment approaches and improve patient management in this context.
Target Audience
Pharmacist
Learning Objectives
1. Define the biochemical mechanisms underlying insulin infusion therapy in reducing triglyceride levels in severe hypertriglyceridemia.
2. Explain the clinical efficacy of insulin infusion therapy for severe hypertriglyceridemia by examining relevant research findings and outcomes.
3. Discuss practical applications and clinical considerations for implementing insulin infusion therapy in patients with severe hypertriglyceridemia.
Additional Information
| Attachment | Size |
|---|---|
 Audience Disclosure slide_27.pptx | 460.3 KB |
 PULSE Handout_Marsa.pdf | 126 KB |
New medications and new guidelines are constantly being released. Pharmacists need a mechanism to keep up with these new medications and guidelines.
Insulin is considered for severe hypertriglyceridemia due to its ability to rapidly lower triglyceride levels through mechanisms such as enhancing lipoprotein lipase activity and reducing hepatic gluconeogenesis. However, the practice lacks standardized guidelines and poses risks like hypoglycemia, necessitating further research to establish optimal dosing, protocols, and long-term outcomes. More randomized controlled trials and mechanistic studies are needed to refine treatment approaches and improve patient management in this context.
Marsa Esmaeili- Koosej, PharmD
In support of improving patient care, the University of Pittsburgh is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.
Pharmacy (CPE)
This knowledge-based activity provides 1.0 contact hours of continuing pharmacy education credit.
Available Credit
- 1.00 ACPE PharmacyThe UPMC Center for Continuing Education in the Health Sciences is accredited by the Accreditation Council for Pharmacy Education (ACPE) as a Provider of continuing pharmacy education.